Recent Research Progress in Mol- Ecular Classification of Gliomas
نویسنده
چکیده
Glial tumours, in particular those of astrocytic origin, are the most common primary brain tumours and account for more than 40% of all central nervous system (CNS) neoplasms (1). All neoplasms have an inherent tendency to progress towards a less differentiated, more malignant phenotype: this change reflects the sequential and cumulative acquisition of genetic alterations (2). Their incidence apart, the complete network of the transformation-associated genes operating in this neoplastic development is still to be fully clarified. Currently, gliomas are classified, in accordance with the World Health Organisation (WHO) scheme (2), on the basis of phenotypic characteristics: tumours with nuclear atypia are classified as grade II (astrocytoma), those showing the addition of mitoses are grade III (anaplastic or malignant astrocytoma) and those exhibiting en-
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